Preparation of vitamin C liposomes by the pH gradient method

LIU Liming, XU Xingmin

doi:10.16774/j.cnki.issn.1674-2214.2015.02.004

Bulletin of Fermentation Science and Technology >

2015 , Vol. 44 >Issue 2: 17 - 19

DOI: https://doi.org/10.16774/j.cnki.issn.1674-2214.2015.02.004

Preparation of vitamin C liposomes by the pH gradient method

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Chemical Engineering College, Qingdao University of Science and Technology, Qingdao 266042, China

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Abstract

Vitamin C liposomes were prepared by the pH gradient method. The entrapment efficiency and the size of vitamin C liposomes were detected by UV-visible spectrophotometry and particle analyzer, respectively. Effects of various factors on the entrapment efficiency including exterior pH, ultrasonic time, incubation temperature and the ratio of drug to lipid, were investigated. The results showed that the entrapment efficiency increased with the decrease of pH and increase
of incubation temperature., The optimal ultrasonic time and ratio of drug to drug was 15 min and 1∶5. The entrapment efficiency of vitamin C liposomes under the optimized conditions was 49.8% and the mean diameter was 118.3 nm.

Key words： vitamin C; liposome; pH gradient method; entrapment efficiency

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LIU Liming, XU Xingmin . Preparation of vitamin C liposomes by the pH gradient method[J]. Bulletin of Fermentation Science and Technology, 2015 , 44(2) : 17 -19 . DOI: 10.16774/j.cnki.issn.1674-2214.2015.02.004

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