The continuous duration of spray drying depended on the material properties and its structure types. When the material is ascertained, the effect of continuous operation mainly depends on the structural type of powder collector of the spray-drying tower. With CGYP01-1000 vertical pressure spray drying tower used in the production of instant tea powder as an example, the spray-drying tower with different structural types of powder collector was compared. In order to avoid the occurrence of the equipment performance problems and improve the drying efficiency, precautions during continuous spray drying and methods for selection of the appropriate powder collector were proposed.