Due to large volume of waste water discharge, ethanol consumption and low viscosity of xanthan gumwhen the fermentation broth was treated by NaOH, a new CaCl2 pretreatment method was developed. To solve low ultrafiltration efficiency of high viscosity liquid and high equipment investment, couple enzymatic hydrolysis method was also employed to remove insoluble substances in fermentation broth and the purity, transmittance and viscosity of final product were improved. The new technology could effectively reduce the consumption of acid, base and ethanol, relieve the pressure of environmental protection facilities. The yield and transmittance of product reached 86.11% and 91% in average, which was increased by 5.96% and 11.97% compared with the traditional process, respectively.