Ｍｅｃｈａｎｉｓｍ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｐｒｏｔｅｉｎ　ｏｎ　ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓｅｒｙｔｈｅｍａｔｏｓｕｓ　ａｎｄ　ｉｔｓ　ｆｕｎｃｔｉｏｎａｌ　ａｎａｌｙｓｉｓ

ＨＵＡＮＧ　Ｊｉｈｏｎｇ，ＪＩ　Ｘｉａｏｇｕｏ，ＺＨＡＮＧ　Ｙｅｑｉ，ＺＨＡＯ　Ｙｉ

doi:10.16774/j.cnki.issn.1674-2214.2017.01.006

Bulletin of Fermentation Science and Technology >

2017 , Vol. 46 >Issue 1: 20 - 24

DOI: https://doi.org/10.16774/j.cnki.issn.1674-2214.2017.01.006

Ｍｅｃｈａｎｉｓｍ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｐｒｏｔｅｉｎ　ｏｎ　ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓｅｒｙｔｈｅｍａｔｏｓｕｓ　ａｎｄ　ｉｔｓ　ｆｕｎｃｔｉｏｎａｌ　ａｎａｌｙｓｉｓ

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Ｓｃｈｏｏｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｅｎｇｉｎｅｅｒｉｎｇ，Ｈｅｎａｎ　Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｔｅｃｈｎｏｌｏｇｙ，Ｚｈｅｎｇｚｈｏｕ　４５０００１，Ｃｈｉｎａ

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Ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓ　ｅｒｙｔｈｅｍａｔｏｓｕｓ（ＳＬＥ）ｉｓ　ｃａｕｓｅｄ　ｂｙ　ｔｈｅ　ｄｉｓｏｒｄｅｒ　ｏｆ　ｉｍｍｕｎｅ　ｓｙｓｔｅｍ　ｏｆ
ｈｕｍａｎ　ｂｏｄｙ　ｆｏｒｍｉｎｇ　ａｎｔｉｂｏｄｉｅｓ　ａｇａｉｎｓｔ　ｈｕｍａｎ　ｏｗｎ　ｏｒｇａｎｓ　ｏｒ　ｔｉｓｓｕｅｓ，ａｎｄ　ｔｈｅ　ｃｕｒｒｅｎｔ　ｔｒｅａｔｍｅｎｔｓ
ｈａｖｅ　ｓｅｒｉｏｕｓ　ａｄｖｅｒｓｅ　ｒｅａｃｔｉｏｎｓ．Ａｃｃｏｒｄｉｎｇ　ｔｏ　ｔｈｅ　ｆｕｌｌ　ｓｐｅｃｔｒｕｍ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｐｒｏｔｅｉｎ，ｔｈｅ
ｐｏｔｅｎｔｉａｌ　ｆｕｎｃｔｉｏｎａｌ　ｐｒｏｔｅｉｎ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｗａｓ　ｃｌａｓｓｉｆｉｅｄ　ａｎｄ　ａｎａｌｙｚｅｄ　ｂｙ　ＧＯ　ｆｕｎｃｔｉｏｎ　ａｎｎｏｔａｔｉｏｎ
ａｎｄ　ＫＥＧＧ　ｍｅｔａｂｏｌｉｃ　ｐａｔｈｗａｙ．Ｔｈｅ　ｍｅｃｈａｎｉｓｍ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｆｕｎｃｔｉｏｎａｌ　ｐｒｏｔｅｉｎ（ｈｉｓｔｏｎｅ）ｏｎ
ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓ　ｅｒｙｔｈｅｍａｔｏｓｕｓ　ｗａｓ　ｅｍｐｈａｔｉｃａｌｌｙ　ａｎａｌｙｚｅｄ．Ｔｈｉｓ　ｐｒｏｖｉｄｅｓ　ｖａｌｕａｂｌｅ　ｉｄｅａｓ　ａｎｄ
ｍｅｔｈｏｄｓ　ｆｏｒ　ｔｈｅ　ｒｅｓｅａｒｃｈ　ａｎｄ　ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ｐｌａｎｔ－ｄｅｒｉｖｅｄ　ｉｍｍｕｎｏｌｏｇｉｃａｌｌｙ　ａｃｔｉｖｅ　ｐｒｏｔｅｉｎｓ，ａｎｄ
ａｌｓｏ　ｐｒｏｖｉｄｅｓ　ｖａｌｕａｂｌｅ　ｎｅｗ　ｒｅｓｏｕｒｃｅｓ　ｆｏｒ　ｍｅｄｉｃｉｎｅ，ｂｉｏｌｏｇｙ　ａｎｄ　ｆｏｏｄ　ｉｎｄｕｓｔｒｉｅｓ．

Key words： ｗｈｅａｔ　ｇｅｒｍ　ｐｒｏｔｅｉｎ; ｍｅｔａｂｏｌｉｃ　ｐａｔｈｗａｙ　ａｎａｌｙｓｉｓ; ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓ　ｅｒｙｔｈｅｍａｔｏｓｕｓ

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ＨＵＡＮＧ　Ｊｉｈｏｎｇ，ＪＩ　Ｘｉａｏｇｕｏ，ＺＨＡＮＧ　Ｙｅｑｉ，ＺＨＡＯ　Ｙｉ . Ｍｅｃｈａｎｉｓｍ　ｏｆ　ｗｈｅａｔ　ｇｅｒｍ　ｐｒｏｔｅｉｎ　ｏｎ　ｓｙｓｔｅｍｉｃ　ｌｕｐｕｓｅｒｙｔｈｅｍａｔｏｓｕｓ　ａｎｄ　ｉｔｓ　ｆｕｎｃｔｉｏｎａｌ　ａｎａｌｙｓｉｓ[J]. Bulletin of Fermentation Science and Technology, 2017 , 46(1) : 20 -24 . DOI: 10.16774/j.cnki.issn.1674-2214.2017.01.006

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