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Overview of metabolic engineering on simultaneousutilization of glucose and xylose by microbes

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  • 1.National and Local United Engineering Lab of Metabolic Control Fermentation Technology,Tianjin 300457,China;
    2.Tianjin Engineering Lab of Efficient and Green Amino Acid Manufacture,Tianjin 300457,China;
    3.College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China

Abstract

At present,as the resource exhaustion and environment pollution problems become
more and more serious,the production of bioproducts including biofules and biomaterials from
agricultural waste and other lignocellulosic feedstocks has attracted a great deal of attention.The
microbial co-utilization of glucose and xylose is essential in lignocellulose biorefinery,and
meanwhile is beneficial in improving fermentation performance for aromatic amino acids.
Nevertheless,because of the existence of carbon catabolite repression (glucose effect),most
microbes dont have this ability.Therefore,it is urgent to construct strains that simultaneously
use glucose and xylose by metabolic engineering technologies.In this study,the significance of
simultaneous utilization of glucose and xylose by microbes was stated,as well as the mechanisms
of glucose effect and its break-down methods in amino acids and nucleotides producing strains
such as Esherichai coli,Bacillus subtilis,and Corynebacterium glutamicum were elaborated.In
addition,the applications of glucose and xylose co-metabolizing strains were introduced.

Cite this article

LI Yanjun,ZHAO Yan,HUANG Longhui , . Overview of metabolic engineering on simultaneousutilization of glucose and xylose by microbes[J]. Bulletin of Fermentation Science and Technology, 2017 , 46(1) : 54 -59 . DOI: 10.16774/j.cnki.issn.1674-2214.2017.01.012

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