At present,as the resource exhaustion and environment pollution problems become
more and more serious,the production of bioproducts including biofules and biomaterials from
agricultural waste and other lignocellulosic feedstocks has attracted a great deal of attention.The
microbial co-utilization of glucose and xylose is essential in lignocellulose biorefinery,and
meanwhile is beneficial in improving fermentation performance for aromatic amino acids.
Nevertheless,because of the existence of carbon catabolite repression (glucose effect),most
microbes dont have this ability.Therefore,it is urgent to construct strains that simultaneously
use glucose and xylose by metabolic engineering technologies.In this study,the significance of
simultaneous utilization of glucose and xylose by microbes was stated,as well as the mechanisms
of glucose effect and its break-down methods in amino acids and nucleotides producing strains
such as Esherichai coli,Bacillus subtilis,and Corynebacterium glutamicum were elaborated.In
addition,the applications of glucose and xylose co-metabolizing strains were introduced.
LI Yanjun,ZHAO Yan,HUANG Longhui ,
. Overview of metabolic engineering on simultaneousutilization of glucose and xylose by microbes[J]. Bulletin of Fermentation Science and Technology, 2017
, 46(1)
: 54
-59
.
DOI: 10.16774/j.cnki.issn.1674-2214.2017.01.012