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The investigation and trend of the transcriptional regulation for the synthesis  of branched chain amino acids in Corynebacteriumglutamicum

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  • 1.College of Biotechnology,Tianjin University of Science and Technology,Tianjin 300457,China;
    2.National and Local United Engineering Lab of Metabolic Control Fermentation Technology,Tianjin 300457,China;
    3.Tianjin Engineering Lab of Efficient and Green Amino Acid Manufacture,Tianjin 300457,China

Abstract

The complicated transcriptional regulation system in Corynebacterium glutamicum,as   well as its unclear regulation mechanism greatly restricted the metabolic engineering strategies    applied to engineer C.glutamicum.Nowadays,a series of investigations have been conducted to   explore the transcriptional regulation network for the synthesis of branched chain amino acids in    C.glutamicum.A number of transcriptional regulators and their targeted regulatory genes have   been identified,while the specific regulatory mechanisms and the interaction between different   regulatory modules remain to be studied in depth.In this paper,the important transcriptional   regulators in the process of carbon metabolism and branched chain amino acid synthesis in
Corynebacterium glutamicum were introduced.

Cite this article

MA Qian,ZHANG Quanwei,SUI Jinting,XIE Xixian . The investigation and trend of the transcriptional regulation for the synthesis  of branched chain amino acids in Corynebacteriumglutamicum[J]. Bulletin of Fermentation Science and Technology, 2017 , 46(3) : 158 -161 . DOI: 10.16774/j.cnki.issn.1674-2214.2017.03.007

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