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Research progress of enzymatic synthesis of chiral amino acids by amidas

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  • College of Biotechnology and Bioengineering,Zhejiang University of Technology,Hangzhou 310014,China

Abstract

Chiral amino acids have been widely used in pharmaceuticals,pesticides,food and   cosmetics industry.It is necessary to develop new,efficient and environmental friendly methods   for the synthesis of chiral amino acids.Amidase possesses a broad substrate spectrum and high    enantioselectivity for the preparation of optically pure amino acids under mild conditions.Here,
the origin,classification,mechanism and application of amidase in the preparation of chiral amino    acids are reviewed.The synthesis of D-phenylalanine,L-tryptophan,L-phenylglycine,O-methyl-D-serine and L-piperazine-2-carboxylic acid was described.The existing problems and future   development of amidase are also discussed.In the near future,an increasing number of novel
amidases will be screened and their potential in the production of chiral amino acids will be further   exploited

Cite this article

GU Chengwei,CAO Chenghao,JIN Liqun,XUE Yaping . Research progress of enzymatic synthesis of chiral amino acids by amidas[J]. Bulletin of Fermentation Science and Technology, 2017 , 46(3) : 162 -169 . DOI: 10.16774/j.cnki.issn.1674-2214.2017.03.008

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