Ｒｅｓｅａｒｃｈ　ａｄｖａｎｃｅ　ｉｎ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｒｏｓｕｖａｓｔａｔｉｎ　ｓｉｄｅ　ｃｈａｉｎ　ｉｎｔｅｒｍｅｄｉａｔｅ &nbsp;ｔｅｒｔ－ｂｕｔｙｌ（３Ｒ，５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３，５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔ

HE Renbao, HU Zhongliang, JIN Yizhong, LIN Jiaohua, ZHANG Xiaojian, WANG Yajun, LIU Zhiqiang

doi:10.16774/j.cnki.issn.1674-2214.2017.03.012

Bulletin of Fermentation Science and Technology >

2017 , Vol. 46 >Issue 3: 188 - 192

DOI: https://doi.org/10.16774/j.cnki.issn.1674-2214.2017.03.012

Ｒｅｓｅａｒｃｈ　ａｄｖａｎｃｅ　ｉｎ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｒｏｓｕｖａｓｔａｔｉｎ　ｓｉｄｅ　ｃｈａｉｎ　ｉｎｔｅｒｍｅｄｉａｔｅｔｅｒｔ－ｂｕｔｙｌ（３Ｒ，５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３，５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔ

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１．Ｚｈｅｊｉａｎｇ　Ｙｏｎｇｔａｉ　Ｔｅｃｈｎｏｌｏｇｙ　Ｃｏ．，Ｌｔｄ．，Ｔａｉｚｈｏｕ　３１７０１６，Ｃｈｉｎａ；
２．Ｋｅｙ　Ｌａｂｏｒａｔｏｒｙ　ｏｆ　Ｂｉｏｏｒｇａｎｉｃ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　Ｚｈｅｊｉａｎｇ
Ｐｒｏｖｉｎｃｅ，Ｃｏｌｌｅｇｅ　ｏｆ　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ　ａｎｄ　Ｂｉｏｅｎｇｉｎｅｅｒｉｎｇ，Ｚｈｅｊｉａｎｇ　Ｕｎｉｖｅｒｓｉｔｙ　ｏｆ　Ｔｅｃｈｎｏｌｏｇｙ，Ｈａｎｇｚｈｏｕ　３１００１４，Ｃｈｉｎａ

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Abstract

Ｒｏｓｕｖａｓｔａｔｉｎ　ｉｓ　ａｎ　ｅｆｆｅｃｔｉｖｅ　３－ｈｙｄｒｏｘｙ－３－ｍｅｔｈｙｌ－ｇｌｕｔａｒｙｌ　ＣｏＡ（ＨＭＧ－ＣｏＡ）ｒｅｄｕｃｔａｓｅｉｎｈｉｂｉｔｏｒ．Ｒｅｇａｒｄｅｄ　ａｓ “ｓｕｐｅｒ－ｓｔａｔｉｎ”，ｒｏｓｕｖａｓｔａｔｉｎ　ｅｆｆｅｃｔｉｖｅｌｙ　ｒｅｄｕｃｅｓ　ｌｏｗ－ｄｅｎｓｉｔｙ　ｌｉｐｏｐｒｏｔｅｉｎ（ＬＤＬ）ｃｈｏｌｅｓｔｅｒｏｌ　ｗｉｔｈｏｕｔ　ａｄｄｉｔｉｏｎａｌ　ａｄｖｅｒｓｅ　ｅｆｆｅｃｔｓ．Ｒｏｓｕｖａｓｔａｔｉｎ　ｉｓ　ｃｏｍｐｏｓｅｄ　ｏｆ　ｔｈｅｈｙｄｒｏｐｈｏｂｉｃ　ｐａｒｅｎｔ　ｎｕｃｌｅｕｓ　ａｎｄ　ｔｈｅ　ｓｉｄｅ　ｃｈａｉｎ，ｗｈｉｌｅ　ｔｈｅ　ｔｈｅ　ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｓｉｄｅ　ｃｈａｉｎ　ｉｓ　ｔｈｅｂｏｔｔｌｅｎｅｃｋ　ｆｏｒ　ｔｈｅ　ｗｈｏｌｅ　ｓｙｎｔｈｅｓｉｓ．Ｃｈｅｍｉｃａｌ　ａｎｄ　ｅｎｚｙｍａｔｉｃ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｒｏｓｕｖａｓｔａｔｉｎ　ｓｉｄｅ
ｃｈａｉｎ　ｉｎｔｅｒｍｅｄｉａｔｅ　ｔｅｒｔ－ｂｕｔｙｌ（３Ｒ，５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３，５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔｅ　ｈａｓ　ａｔｔｒａｃｔｅｄｉｎｃｒｅａｓｉｎｇ　ａｔｔｅｎｔｉｏｎｓ．Ｒｅｓｅａｒｃｈ　ｐｒｏｇｒｅｓｓ　ｉｎ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｅｒｔ－ｂｕｔｙｌ（３Ｒ，５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３，５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔｅ　ｗａｓ　ｒｅｖｉｅｗｅｄ　ｉｎ　ｔｈｉｓ　ｐａｐｅｒ．

Key words： ｔｅｒｔ－ｂｕｔｙｌ（３Ｒ; ５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３; ５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔｅ; ｒｏｓｕｖａｓｔａｔｉｎ; ｃｈｉｒａｌ ; ｉｎｔｅｒｍｅｄｉａｔｅｓ; ａｓｙｍｍｅｔｒｉｃ　ｒｅａｃｔｉｏｎ

Cite this article

HE Renbao, HU Zhongliang, JIN Yizhong, LIN Jiaohua, ZHANG Xiaojian, WANG Yajun, LIU Zhiqiang . Ｒｅｓｅａｒｃｈ　ａｄｖａｎｃｅ　ｉｎ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｒｏｓｕｖａｓｔａｔｉｎ　ｓｉｄｅ　ｃｈａｉｎ　ｉｎｔｅｒｍｅｄｉａｔｅｔｅｒｔ－ｂｕｔｙｌ（３Ｒ，５Ｓ）－６－Ｒ－ｓｕｂｓｔｉｔｕｅｎｔ－３，５－ｄｉｈｙｄｒｏｘｙｈｅｘａｎｏａｔ[J]. Bulletin of Fermentation Science and Technology, 2017 , 46(3) : 188 -192 . DOI: 10.16774/j.cnki.issn.1674-2214.2017.03.012

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